Publications

2024

Corticolimbic circuitry as a druggable target in schizophrenia spectrum disorders: a narrative review

Gee A, Dazzan P, Grace AA, Modinos, G.

Transl Psychiatry (accepted/in press).

Towards a consensus roadmap for a new diagnostic framework for mental disorders

Kas MJH, Hyman S, Williams LM, Hidalgo-Mazzei D, Huys QJM, Hotopf M, Cuthbert B, Lewis CM, De Picker LJ, Lalousis PA, Etkin A, Modinos G, Marston HM.

Eur Neuropsychopharmacol. 2024 Sep 27;90:16-27.

*PREPRINT* - Multiscale characterization of cortical signatures in positive and negative schizotypy: A worldwide ENIGMA study

Matthias Kirschner, Benazir Hodzic-Santor, Leda Kennedy, Justine Y. Hansen, Mathilde Antoniades, Igor Nenadić, Tilo Kircher, Axel Krug, Tina Meller, Udo Dannlowski, Dominik Grotegerd, Kira Flinkenflügel, Susanne Meinert, Tiana Borgers, Janik Goltermann, Tim Hahn, Joscha Böhnlein, Elisabeth J. Leehr, Carlotta Barkhau, Alex Fornito, Aurina Arnatkeviciute, Mark A. Bellgrove, Jeggan Tiego, Pamela DeRosse, Melissa Green, Yann Quidé, Christos Pantelis, Raymond Chan, Yi Wang, Ulrich Ettinger, Martin Debbané, Melodie Derome, Christian Gaser, Bianca Besteher, Kelly Diederen, Tom J. Spencer, Josselin Houenou, Edith Pomarol-Clotet, Raymond Salvador, Wulf Rössler, Lukasz Smigielski, Veena Kumari, Preethi Premkumar, Haeme R. P. Park, Kristina Wiebels, Imke Lemmers-Jansen, James Gilleen, Paul Allen, Jan-Bernard Marsman, Irina Lebedeva, Alexander Tomyshev, Anne-Kathrin Fett, Iris Sommer, Sanne Koops, Phillip Grant, Indrit Bègue, Dennis Hernaus, Maria Jalbrzikowski, Casey Paquola, Sara Larivière, Boris Bernhardt, Sofie Valk, Bratislav Misic, Theo G. M. van Erp, Jessica A. Turner, Paul M. Thompson, Andre Aleman, Alain Dagher, Stefan Kaiser, Gemma Modinos.

medRxiv 2024.05.03.24306736; doi: https://doi.org/10.1101/2024.05.03.24306736.

Effects of Diazepam on Hippocampal Blood Flow in People at Clinical High Risk for Psychosis

Livingston NR, Kiemes A, Devenyi GA, Knight S, Lukow PB, Jelen L, Reilly T, Dima A, Nettis MA, Casetta C, Agyekum T, Zelaya F, Spencer T, De Micheli A, Fusar-Poli P, Grace AA, Williams SCR, McGuire P, Egerton A, Chakravarty MM, Modinos G.

Neuropsychopharmacology. 2024 Apr 24; doi: 10.1038/s41386-024-01864-9.

*PREPRINT* - Transcriptional and neurochemical signatures of cerebral blood flow alterations in schizophrenia and the clinical high-risk state for psychosis

Knight SR, Abbasova L, Zeighami Y, Hansen JY, Martins D, Zelaya F, Dipasquale O, Liu T, Shin D, Bossong MG, Azis M, Antoniades M, Howes O, Bonoldi I, Egerton A, Allen P, O’Daly O, McGuire P, Modinos G.

bioRxiv 2024.03.13.583894; doi: https://doi.org/10.1101/2024.03.13.583894

Effects of Benzodiazepine Exposure on Real-World Clinical Outcomes in Individuals at Clinical High-Risk for Psychosis

Livingston NR, De Micheli A, McCutcheon RA, Butler E, Hamdan M, Grace AA, McGuire P, Egerton A, Fusar-Poli P, Modinos G.

Schizophrenia Bulletin. 2024 Apr 3; sbae036. doi: 10.1093/schbul/sbae036.

PsyCog: A computerised mini battery for assessing cognition in psychosis.

Gifford G, Cullen AE, Vieira S, Searle A, McCutcheon RA, Modinos G, Stone WS, Hird E, Barnett J, van Hell HH, Catalan A, Millgate E, Taptiklis N, Cormack F, Slot ME, Dazzan P, Maat A, de Haan L, Facorro BC, Glenthøj B, Lawrie SM, McDonald C, Gruber O, van Amelsvoort T, Arango C, Kircher T, Nelson B, Galderisi S, Bressan RA, Kwon JS, Weiser M, Mizrahi R, Sachs G, Kirschner M, Reichenberg A; PSYSCAN Consortium; Kahn R, McGuire P.

Schizophr Res Cogn. 2024 Mar 28;37:100310. doi: 10.1016/j.scog.2024.100310.

Letter to the Editor on 'Baseline benzodiazepine exposure is associated with greater risk of transition in clinical high-risk for psychosis (CHR-P): a meta-analysis'

Livingston NR, Fusar-Poli P, Modinos G.

Psychological Medicine. 2024 Jan; 54(1):215-216. doi: 10.1017/S0033291723003203.

Childhood trauma moderates schizotypy-related brain morphology: analyses of 1182 healthy individuals from the ENIGMA schizotypy working group

Quidé Y, Watkeys OJ, Tonini E, Grotegerd D, Dannlowski U, Nenadić I, Kircher T, Krug A, Hahn T, Meinert S, Goltermann J, Gruber M, Stein F, Brosch K, Wroblewski A, Thomas-Odenthal F, Usemann P, Straube B, Alexander N, Leehr EJ, Bauer J, Winter NR, Fisch L, Dohm K, Rössler W, Smigielski L, DeRosse P, Moyett A, Houenou J, Leboyer M, Gilleen J, Thomopoulos SI, Thompson PM, Aleman A, Modinos G, Green MJ.

Psychological Medicine. 2023 Oct 20:1-13.

Erbb4 deletion from inhibitory interneurons causes psychosis-relevant neuroimaging phenotypes

Kiemes A, Serrano Navacerrada ME, Kim E, Bernard C, Randall K, Simmons C, Gonzalez LR, Lythgoe D, Rotaru D, Vernon AC, Cash D*, Modinos G.*

Schizophrenia Bulletin. 2023 May 3;49(3):569-580.

Featured in EDITORIAL: Heckers S, Konradi C (2023). Animal model reveals mechanism of hippocampal hyperactivity in psychosis. Schizophrenia Bulletin; 2023 May 3;49(3):546-548.

Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis.

Merritt K, McCutcheon RA, Aleman A, Ashley S, Beck K, Block W, Bloemen OJN, Borgan F, Boules C, Bustillo JR, Capizzano AA, Coughlin JM, David A, de la Fuente-Sandoval C, Demjaha A, Dempster K, Do KQ, Du F, Falkai P, Galińska-Skok B, Gallinat J, Gasparovic C, Ginestet CE, Goto N, Graff-Guerrero A, Ho BC, Howes O, Jauhar S, Jeon P, Kato T, Kaufmann CA, Kegeles LS, Keshavan MS, Kim SY, King B, Kunugi H, Lauriello J, León-Ortiz P, Liemburg E, Mcilwain ME, Modinos G, Mouchlianitis E, Nakamura J, Nenadic I, Öngür D, Ota M, Palaniyappan L, Pantelis C, Patel T, Plitman E, Posporelis S, Purdon SE, Reichenbach JR, Renshaw PF, Reyes-Madrigal F, Russell BR, Sawa A, Schaefer M, Shungu DC, Smesny S, Stanley JA, Stone J, Szulc A, Taylor R, Thakkar KN, Théberge J, Tibbo PG, van Amelsvoort T, Walecki J, Williamson PC, Wood SJ, Xin L, Yamasue H, McGuire P, Egerton A; 1H-MRS in Schizophrenia Investigators.

Molecular Psychiatry. 2023; Feb 17. doi: 10.1038/s41380-023-01991-7.

Parsing neurobiological heterogeneity of the clinical high-risk state for psychosis: A pseudo-continuous arterial spin labelling study.

Oliver D, Davies C, Zelaya F, Selvaggi P, De Micheli A, Catalan A, Baldwin H, Arribas M, Modinos G, Crossley NA, Allen P, Egerton A, Jauhar S, Howes OD, McGuire P, Fusar-Poli P.

Frontiers in Psychiatry. 2023; Mar 8;14:1092213.

Neurofunctional correlates of glutamate and GABA imbalance in psychosis: A systematic review

Zahid U, Onwordi EC, Hedges EP, Wall MB, Modinos G, Murray RM, Egerton A.

Neuroscience & Biobehavioral Reviews. 2023 Jan; 144:105010.

2021

Cortical and Subcortical Neuroanatomical Signatures of Schizotypy in 3,004 Individuals Assessed in a Worldwide ENIGMA Study

Matthias Kirschner, Benazir Hodzic-Santor, Mathilde antoniades, Igor nenadic, Tilo Kircher, Axel Krug, Tina Meller, Dominik Grotegerd, Alex Fornito, Aurina Arnatkeviciute, Mark Bellgrove, Jeggan Tiego, Udo Dannlowski, Katharina Koch, Carina Huelsmann, Harald Kugel, Verena Enneking, Melissa Klug, Elisabeth J. Leehr, Joscha Boehnlein, Marius Gruber, David M.A. Mehler, Pamela DeRosse, Ashley Moyett, Bernhard T. Baune, Melissa Green, Yann Quide, Christos Pantelis, Raymond C K Chan, Yi Wang, Ulrich Ettinger, Martin Debbane, Melodie Derome, Christian Gaser, Bianca Besteher, Kelly Diederen, Tom Spencer, Paul Fletcher, Wulf Roessler, Lukasz Smigielski, Veena Kumari, Preethi Premkumar, Haeme R. P. Park, Kristina Wiebels, Imke Lemmers-Jansen, James Gilleen, Paul Allen, Petra Kozhuharova, Jan-Bernard C. Marsman, Irina Lebedeva, Alexander Tomyshev, Anna Mukhorina, Stefan Kaiser, Anne-Kathrin Fett, Iris Sommer, Sanne Schuite-Koops, Casey Paquola, Sara Lariviere, Boris B. Bernhardt, Alain Dagher, Phillip Grant, Theo G. M. van Erp, Jessica Turner, Paul Thompson, Andre Aleman, Gemma Modinos.

Molecular Psychiatry. 2021. Oct 27. doi: 10.1038/s41380-021-01359-9.

GABA-A and NMDA receptor density alterations and their behavioral correlates in the gestational methylazoxymethanol acetate model for schizophrenia

Amanda Kiemes, Felipe V Gomes, Diana Cash, Daniela L Uliana, Camilla Simmons, Nisha Singh, Anthony C Vernon, Federico E Turkheimer, Cathy Davies, James M Stone, Anthony A Grace, Gemma Modinos.

Neuropsychopharmacology. 2021. Nov 6. doi: 10.1038/s41386-021-01213-0.

Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis

Hedges EP, Dickson H, Tognin S, Modinos G, Antoniades M, van der Gaag M, de Haan L, McGorry P, Pantelis C, Riecher-Rössler A, Bressan R, Barrantes-Vidal N, Krebs MO, Nordentoft M, Ruhrmann S, Sachs G, Rutten BP, van Os J; EU-GEI High Risk Study, Valmaggia LR, McGuire P, Kempton MJ.

Schizophrenia Research: Cognition. 2021 Oct 28;28:100222.

Adverse clinical outcomes in people at clinical high-risk for psychosis related to altered interactions between hippocampal activity and glutamatergic function

Allen P, Hird EJ, Orlov N, Modinos G, Bossong M, Antoniades M, Sampson C, Azis M, Howes O, Stone J, Perez J, Broome M, Grace AA, McGuire P.

Translational Psychiatry. 2021 Nov 10;11(1):579.

Interactions between hippocampal activity and striatal dopamine in people at clinical high risk for psychosis: relationship to clinical outcomes

Modinos G*, Richter A*, Egerton A, Bonoldi A, Azis M, Antoniades M, Bossong M, Crossley N, Perez J, Stone JM, Veronese M, Zelaya F, Grace AA, Howes OD, Allen P, McGuire P.

Neuropsychopharmacology. 2021. Jul;46(8):1468-1474.

Association of Age, Antipsychotic Medication, and Symptom Severity in Schizophrenia With Proton Magnetic Resonance Spectroscopy Brain Glutamate Level

Merritt K, McGuire PK, Egerton A; 1H-MRS in Schizophrenia Investigators, Aleman A, Block W, Bloemen OJN, Borgan F, Bustillo JR, Capizzano AA, Coughlin JM, De la Fuente-Sandoval C, Demjaha A, Dempster K, Do KQ, Du F, Falkai P, Galinska-Skok B, Gallinat J, Gasparovic C, Ginestet CE, Goto N, Graff-Guerrero A, Ho BC, Howes OD, Jauhar S, Jeon P, Kato T, Kaufmann CA, Kegeles LS, Keshavan M, Kim SY, Kunugi H, Lauriello J, Liemburg EJ, Mcilwain ME, Modinos G, Mouchlianitis ED, Nakamura J, Nenadic I, Öngür D, Ota M, Palaniyappan L, Pantelis C, Plitman E, Posporelis S, Purdon SE, Reichenbach JR, Renshaw PF, Russell BR, Sawa A, Schaefer M, Shungu DC, Smesny S, Stanley JA, Stone JM, Szulc A, Taylor R, Thakkar K, Théberge J, Tibbo PG, van Amelsvoort T, Walecki J, Williamson PC, Wood SJ, Xin L, Yamasue H.

JAMA Psychiatry. 2021. Jun 1;78(6):667-681.

The neural correlates of emotional processing in psychosis risk and onset – a systematic review and meta-analysis of fMRI studies

Lukow PB, Kiemes A, Kempton MJ, Turkheimer FE, McGuire P, Modinos G.

Neuroscience and Biobehavioral Reviews. 2021 Mar 12:S0149-7634(21)00123-8.

GABA, glutamate and neural activity: a systematic review with meta-analysis of multimodal 1H-MRS-fMRI studies

Kiemes A, Davies C, Kempton MJ, Lukow PB, Bennallick C, Stone JM, Modinos G.

Frontiers in Psychiatry. 2021 Mar 8;12:644315.

2020

Region-specific and dose-specific effects of chronic haloperidol exposure on [3H]Flumazenil and [3H]Ro15-4513 GABAA receptor binding sites in the rat brain

Peris-Yague A, Kiemes A, Cash D, Cotel MC, Singh N, Vernon AC*, Modinos G*.

European Neuropsychopharmacology. 2020 Dec;41:106-117.

Integrated metastate functional connectivity networks predict change in symptom severity in clinical high risk for psychosis

Gifford G, Crossley N, Morgan S, Kempton MJ, Dazzan P, Modinos G, Azis M, Samson C, Bonoldi I, Quinn B, Smart SE, Antoniades M, Bossong MG, Broome MR, Perez J, Howes OD, Stone JM, Allen P, Grace AA, McGuire P.

Hum Brain Mapp. 2020 Oct 13;42(2):439-51.

Support Early-Career Researchers for Post-Pandemic Prospects

Husby A, Modinos G.

Nature. 2020 Apr;580(7802):185.

ENIGMA and Global Neuroscience: A Decade of Large-Scale Studies of the Brain in Health and Disease Across More Than 40 Countries

Thompson PM, Jahanshad N, Ching CRK, Salminen LE, Thomopoulos SI, Bright J, Baune BT, Bertolín S, Bralten J, Bruin WB, Bülow R, Chen J, Chye Y, Dannlowski U, de Kovel CGF, Donohoe G, Eyler LT, Faraone SV, Favre P, Filippi CA, Frodl T, Garijo D, Gil Y, Grabe HJ, Grasby KL, Hajek T, Han LKM, Hatton SN, Hilbert K, Ho TC, Holleran L, Homuth G, Hosten N, Houenou J, Ivanov I, Jia T, Kelly S, Klein M, Kwon JS, Laansma MA, Leerssen J, Lueken U, Nunes A, Neill JO, Opel N, Piras F, Piras F, Postema MC, Pozzi E, Shatokhina N, Soriano-Mas C, Spalletta G, Sun D, Teumer A, Tilot AK, Tozzi L, van der Merwe C, Van Someren EJW, van Wingen GA, Völzke H, Walton E, Wang L, Winkler AM, Wittfeld K, Wright MJ, Yun JY, Zhang G, Zhang-James Y, Adhikari BM, Agartz I, Aghajani M, Aleman A, Althoff RR, Altmann A, Andreassen OA, Baron DA, Bartnik-Olson BL, Marie Bas-Hoogendam J, Baskin-Sommers AR, Bearden CE, Berner LA, Boedhoe PSW, Brouwer RM, Buitelaar JK, Caeyenberghs K, Cecil CAM, Cohen RA, Cole JH, Conrod PJ, De Brito SA, de Zwarte SMC, Dennis EL, Desrivieres S, Dima D, Ehrlich S, Esopenko C, Fairchild G, Fisher SE, Fouche JP, Francks C, Frangou S, Franke B, Garavan HP, Glahn DC, Groenewold NA, Gurholt TP, Gutman BA, Hahn T, Harding IH, Hernaus D, Hibar DP, Hillary FG, Hoogman M, Hulshoff Pol HE, Jalbrzikowski M, Karkashadze GA, Klapwijk ET, Knickmeyer RC, Kochunov P, Koerte IK, Kong XZ, Liew SL, Lin AP, Logue MW, Luders E, Macciardi F, Mackey S, Mayer AR, McDonald CR, McMahon AB, Medland SE, Modinos G, Morey RA, Mueller SC, Mukherjee P, Namazova-Baranova L, Nir TM, Olsen A, Paschou P, Pine DS, Pizzagalli F, Rentería ME, Rohrer JD, Sämann PG, Schmaal L, Schumann G, Shiroishi MS, Sisodiya SM, Smit DJA, Sønderby IE, Stein DJ, Stein JL, Tahmasian M, Tate DF, Turner JA, van den Heuvel OA, van der Wee NJA, van der Werf YD, van Erp TGM, van Haren NEM, van Rooij D, van Velzen LS, Veer IM, Veltman DJ, Villalon-Reina JE, Walter H, Whelan CD, Wilde EA, Zarei M, Zelman V; ENIGMA Consortium.

Transl Psychiatry. 2020 Mar 20;10(1):100.

Developmental Trajectories of Subcortical Structures in Relation to Dimensional Schizotypy Expression Along Adolescence

Derome M, Zöller D, Modinos G, Schaer M, Eliez S, Debbané M.

Schizophr Res. 2020 Apr;218:76-84.

Emotion Recognition and Adverse Childhood Experiences in Individuals at Clinical High Risk of Psychosis

Tognin S, Catalan A, Modinos G, Kempton MJ, Bilbao A, Nelson B, Pantelis C, Riecher-Rössler A, Bressan R, Barrantes-Vidal N, Krebs M-O, Nordentoft M, Ruhrmann S, Sachs G, Rutten BPF, van Os J, de Haan L, van der Gaag M, EU-GEI High Risk Study, McGuire P, Valmaggia LR.

Schizophr Bull. 2020 Jul 8;46(4):823-833.

2019

Association of Adverse Outcomes With Emotion Processing and Its Neural Substrate in Individuals at Clinical High Risk for Psychosis

Modinos G, Kempton MJ, Tognin S, Calem M, Porffy L, Antoniades M, Mason A, Azis M, Allen P, Nelson B, McGorry P, Pantelis C, Riecher-Rössler A, Borgwardt S, Bressan R, Barrantes-Vidal N, Krebs MO, Nordentoft M, Glenthøj B, Ruhrmann S, Sachs G, Rutten B, van Os J, de Haan L, Velthorst E, van der Gaag M, Valmaggia LR, McGuire P; EU-GEI High Risk Study Group.

JAMA Psychiatry. 2019 Nov 13. 77(2):190-200.

Glutamatergic and dopaminergic function and the relationship to outcome in people at clinical high risk of psychosis: a multi-modal PET-magnetic resonance brain imaging study

Howes OD, Bonoldi I, McCutcheon RA, Azis M, Antoniades M, Bossong M, Modinos G, Perez J, Stone JM, Santangelo B, Veronese M, Grace A, Allen P, McGuire PK.

Neuropsychopharmacology. 2019 Oct 16. 45(4):641-648.

Towards Precision Medicine in Psychosis: Benefits and Challenges of Multimodal Multicenter Studies-PSYSCAN: Translating Neuroimaging Findings From Research into Clinical Practice

Tognin S, van Hell HH, Merritt K, Winter-van Rossum I, Bossong MG, Kempton MJ, Modinos G, Fusar-Poli P, Mechelli A, Dazzan P, Maat A, De Haan L, Crespo-Facorro B, Glenthøj B, Lawrie SM, McDonald C, Gruber O, van Amelsvoort T, Arango Lopez C, Kircher T, Nelson B, Galderisi S, Bressan R, Kwon JS, Weiser M, Mizrahi R, Sachs G2, Maatz A, Kahn R, McGuire P; PSYSCAN Consortium.

Schizophr Bull. 2019 Aug 19. pii: sbz067.

Neural Circuitry of Novelty Salience Processing in Psychosis Risk: Association with Clinical Outcome

Modinos G, Allen PA, Zugman A, Dima D, Azis M, Samson C, Bonoldi I, Quinn B, Gifford GWG, Smart SE, Antoniades M, Bossong MG, Broome MR, Perez J, Howes OD, Stone JM, Grace AA, McGuire P.

Schizophr Bull. 2020 Apr 10;46(3):670-679.

Basic Self-Disturbances Related to Reduced Anterior Cingulate Volume in Subjects at Ultra-High Risk for Psychosis

Bonoldi I, Allen P, Madeira L, Tognin S, Bossong MG, Azis M, Samson C, Quinn B, Calem M, Valmaggia L, Modinos G, Stone J, Perez J, Howes O, Politi P, Kempton MJ, Fusar-Poli P, McGuire P.

Front Psychiatry. 2019 May 10;10:254.

Oxytocin modulates hippocampal perfusion in people at clinical high risk for psychosis

Davies C, Paloyelis Y, Rutigliano G, Cappucciati M, De Micheli A, Ramella-Cravaro V, Provenzani U, Antoniades M, Modinos G, Oliver D, Stahl D, Murguia S, Zelaya F, Allen, P, Shergill S, Morrison P, Williams S, Taylor D, McGuire P. & Fusar-Poli, P.

Neuropsychopharmacology. 2019 Jun;44(7):1300-1309.

Multi-echo fMRI, resting-state connectivity, and high psychometric schizotypy

Waltmann M, O'Daly O, Egerton A, McMullen K, Kumari V, Barker GJ, Williams SCR, Modinos G.

Neuroimage Clin. 2019;21:101603.

2018

Association of hippocampal glutamate levels with adverse outcomes in individuals at clinical high risk for psychosis

Bossong MG, Antoniades M, Azis M, Samson C, Quinn B, Bonoldi I, Modinos G, Perez J, Howes OD, Stone JM, Allen P, McGuire P.

JAMA Psychiatry. 2018 Nov 14. (2019;76(2):199-207.)

Increased resting perfusion of the hippocampus in high positive schizotypy: A pseudocontinuous arterial spin labeling study

Modinos G, Egerton A, McMullen K, McLaughlin A, Kumari V, Barker GJ, Williams SCR, Zelaya F.

Hum Brain Mapp. 2018 Oct;39(10):4055-4064.

Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis

Modinos G, Şimşek F, Azis M, Bossong M, Bonoldi I, Samson C, Quinn B, Perez J, Broome MR, Zelaya F, Lythgoe DJ, Howes OD, Stone JM, Grace AA, Allen P, McGuire P.

Neuropsychopharmacology. 2018 Dec;43(13):2660

Cortical GABA in Subjects at Ultra-High Risk of Psychosis: Relationship to Negative Prodromal Symptoms

Modinos G, Şimşek F, Horder J, Bossong M, Bonoldi I, Azis M, Perez J, Broome M, Lythgoe DJ, Stone JM, Howes OD, Murphy DG, Grace AA, Allen P, McGuire P.

Int J Neuropsychopharmacol. 2018 Feb 1;21(2):114-119

Increased Resting Hippocampal and Basal Ganglia Perfusion in People at Ultra High Risk for Psychosis: Replication in a Second Cohort

Allen P, Azis M, Modinos G, Bossong MG, Bonoldi I, Samson C, Quinn B, Kempton MJ, Howes OD, Stone JM, Calem M, Perez J, Bhattacharayya S, Broome MR, Grace AA, Zelaya F, McGuire P.

Schizophr Bull. 2018 Oct 17;44(6):1323-1331

Neuroanatomical changes in people with high schizotypy: relationship to glutamate levels

Modinos G, Egerton A, McLaughlin A, McMullen K, Kumari V, Lythgoe DJ, Barker GJ, Aleman A, Williams SCR.

Psychol Med. 2018 Aug;48(11):1880-1889

2017

Phenomenology and Social Agent Representation in Psychosis: A Welcome Integration

Bell V, Mills KL, Modinos G, Wilkinson S.

Clin Psychol Sci. 2017 Sep;5(5):769-770.

Neuroimaging studies of GABA in schizophrenia: a systematic review with meta-analysis

Egerton A, Modinos G, Ferrera D, McGuire P.

Transl Psychiatry. 2017 Jun 6;7(6):e1147.

Rethinking Social Cognition in Light of Psychosis: Reciprocal Implications for Cognition and Psychopathology

Bell V, Mills KL, Modinos G, Wilkinson S.

Clin Psychol Sci. 2017 May;5(3):537-550.

Corticolimbic hyper-response to emotion and glutamatergic function in people with high schizotypy: a multimodal fMRI-MRS study

Modinos G, McLaughlin A, Egerton A, McMullen K, Kumari V, Barker GJ, Keysers C, Williams SC.

Transl Psychiatry. 2017 Apr 4;7(4):e1083

2016

Corticolimbic dysfunction during facial and prosodic emotional recognition in first-episode psychosis patients and individuals at ultra-high risk

Tseng HH, Roiser JP, Modinos G, Falkenberg I, Samson C, McGuire P, Allen P.

Neuroimage Clin. 2016 Sep 8;12:645-654.

2015

A systematic review of multisensory cognitive-affective integration in schizophrenia

Tseng HH, Bossong MG, Modinos G, Chen KM, McGuire P, Allen P.

Neurosci Biobehav Rev. 2015 Aug;55:444-52

Failure to deactivate medial prefrontal cortex in people at high risk for psychosis

Falkenberg I, Chaddock C, Murray RM, McDonald C, Modinos G, Bramon E, Walshe M, Broome M, McGuire P, Allen P.

Eur Psychiatry. 2015 Jul;30(5):633-40.

Neural correlates of aberrant emotional salience predict psychotic symptoms and global functioning in high-risk and first-episode psychosis

Modinos G, Tseng HH, Falkenberg I, Samson C, McGuire P, Allen P.

Soc Cogn Affect Neurosci. 2015 Oct;10(10):1429-36.

Translating the MAM model of psychosis to humans

Modinos G, Allen P, Grace AA, McGuire P.

Trends Neurosci. 2015 Mar;38(3):129-38.

The prodromal phase of psychosis

Modinos G, McGuire P.

Curr Opin Neurobiol. 2015 Feb;30:100-5

2014

Are we really mapping psychosis risk? Neuroanatomical signature of affective disorders in subjects at ultra high risk

Modinos G, Allen P, Frascarelli M, Tognin S, Valmaggia L, Xenaki L, Keedwell P, Broome M, Valli I, Woolley J, Stone JM, Mechelli A, Phillips ML, McGuire P, Fusar-Poli P.

Psychol Med. 2014 Dec;44(16):3491-501

Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations

European Network of National Networks studying Gene-Environment Interactions in Schizophrenia (EU-GEI).

Schizophr Bull. 2014 Jul;40(4):729-36

2013

Voxel-based gray and white matter morphometry correlates of hallucinations in schizophrenia: The superior temporal gyrus does not stand alone

van Tol MJ, van der Meer L, Bruggeman R, Modinos G, Knegtering H, Aleman A.

Neuroimage Clin. 2013 Dec 29;4:249-57

Molecular genetic gene-environment studies using candidate genes in schizophrenia: a systematic review.

Modinos G, Iyegbe C, Prata D, Rivera M, Kempton MJ, Valmaggia LR, Sham PC, van Os J, McGuire P.

Schizophr Res. 2013 Nov;150(2-3):356-65

Pattern classification of brain activation during emotional processing in subclinical depression: psychosis proneness as potential confounding factor

Modinos G, Mechelli A, Pettersson-Yeo W, Allen P, McGuire P, Aleman A.

PeerJ. 2013 Feb 26;1:e42.

Neuroanatomy of auditory verbal hallucinations in schizophrenia: a quantitative meta-analysis of voxel-based morphometry studies

Modinos G, Costafreda SG, van Tol MJ, McGuire PK, Aleman A, Allen P.

Cortex. 2013 Apr;49(4):1046-55

2012

Neuroimaging auditory hallucinations in schizophrenia: from neuroanatomy to neurochemistry and beyond

Allen P, Modinos G, Hubl D, Shields G, Cachia A, Jardri R, Thomas P, Woodward T, Shotbolt P, Plaze M, Hoffman R.

Schizophr Bull. 2012 Jun;38(4):695-703.

Multivariate pattern classification reveals differential brain activation during emotional processing in individuals with psychosis proneness

Modinos G, Pettersson-Yeo W, Allen P, McGuire PK, Aleman A, Mechelli A.

Neuroimage. 2012 Feb 1;59(3):3033-41

2011

Self-reflection and the psychosis-prone brain: an fMRI study

Modinos G, Renken R, Ormel J, Aleman A.

Neuropsychology. 2011 May;25(3):295-305

2009

Structural covariance in the hallucinating brain: a voxel-based morphometry study

Modinos G, Vercammen A, Mechelli A, Knegtering H, McGuire PK, Aleman A.

J Psychiatry Neurosci. 2009 Nov;34(6):465-9.

Cortisol levels in childhood and psychosis risk in late adolescence

Modinos G, Aleman A, Ormel J.

J Am Acad Child Adolesc Psychiatry. 2009 Jul;48(7):765-6

Theory of Mind in different dementia profiles

Modinos G, Obiols JE, Pousa E, Vicens J.

J Neuropsychiatry Clin Neurosci. 2009 Winter;21(1):100-1.

Activation of anterior insula during self-reflection

Modinos G, Ormel J, Aleman A.

PLoS One. 2009;4(2):e4618

Detection of visuoperceptual deficits in preclinical and mild Alzheimer's disease

Alegret M, Boada-Rovira M, Vinyes-Junqué G, Valero S, Espinosa A, Hernández I, Modinos G, Rosende-Roca M, Mauleón A, Becker JT, Tárraga L.

J Clin Exp Neuropsychol. 2009 Oct;31(7):860-7

2006

A randomised pilot study to assess the efficacy of an interactive, multimedia tool of cognitive stimulation in Alzheimer's disease

Tárraga L, Boada M, Modinos G, Espinosa A, Diego S, Morera A, Guitart M, Balcells J, López OL, Becker JT.

J Neurol Neurosurg Psychiatry. 2006 Oct;77(10):1116-21.